Brain network connectivity in individuals with schizophrenia and their siblings.

ABSTRACT:

Background

Research on brain activity in schizophrenia has shown that changes in the function of any single region cannot explain the range of cognitive and affective impairments in this illness. Rather, neural circuits that support sensory, cognitive, and emotional processes are now being investigated as substrates for cognitive and affective impairments in schizophrenia, a shift in focus consistent with long-standing hypotheses about schizophrenia as a disconnection syndrome. Our goal was to further examine alterations in functional connectivity within and between the default mode network and three cognitive control networks (frontal-parietal, cingulo-opercular, and cerebellar) as a basis for such impairments.

Methods

Resting state functional magnetic resonance imaging was

SUBMITTER: Repovs G 

PROVIDER: S-EPMC3081915 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature