Increasing tumoral 5-fluorouracil concentrations during a 5-day continuous infusion: a microdialysis study.

ABSTRACT:

Purpose

Response to anticancer therapy is believed to be directly related to the concentration of the anticancer drug in the tumor itself. Assessment of intra-tumor drug pharmacokinetics can be helpful to gain more insight into mechanisms involved in the (in)sensitivity of tumors to anticancer therapy. We explored the pharmacokinetics of 5-fluorouracil in both plasma and tumor tissue during a 5-day continuous infusion of 5-fluorouracil in patients with cancer. Sampling for measurement of 5-fluorouracil in tumor tissue was performed using microdialysis.

Experimental design

In seven patients with an accessible (sub)cutaneous tumor treated with a continuous 5-fluorouracil infusion, plasma and microdialysate samples from tumor and normal adipose tissue were collected over a peri

SUBMITTER: Konings IR 

PROVIDER: S-EPMC3082021 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature