Computational study of associations between histone modification and protein-DNA binding in yeast genome by integrating diverse information.

ABSTRACT:

Background

In parallel with the quick development of high-throughput technologies, in vivo (vitro) experiments for genome-wide identification of protein-DNA interactions have been developed. Nevertheless, a few questions remain in the field, such as how to distinguish true protein-DNA binding (functional binding) from non-specific protein-DNA binding (non-functional binding). Previous researches tackled the problem by integrated analysis of multiple available sources. However, few systematic studies have been carried out to examine the possible relationships between histone modification and protein-DNA binding. Here this issue was investigated by using publicly available histone modification data in yeast.

Results

Two separate histone modification datasets were studied, at b

SUBMITTER: Wang J 

PROVIDER: S-EPMC3082246 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature