Cardiac progenitor cell commitment is inhibited by nuclear Akt expression.

ABSTRACT:

Rationale

Stem cell therapies to regenerate damaged cardiac tissue represent a novel approach to treat heart disease. However, the majority of adoptively transferred stem cells delivered to damaged myocardium do not survive long enough to impart protective benefits, resulting in modest functional improvements. Strategies to improve survival and proliferation of stem cells show promise for significantly enhancing cardiac function and regeneration.

Objective

To determine whether injected cardiac progenitor cells (CPCs) genetically modified to overexpress nuclear Akt (CPCeA) increase structural and functional benefits to infarcted myocardium relative to control CPCs.

Methods and results

CPCeA exhibit significantly increased proliferation and secretion of paracrine factor

SUBMITTER: Fischer KM 

PROVIDER: S-EPMC3082319 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature