Potential associations between severity of infection and the presence of virulence-associated genes in clinical strains of Staphylococcus aureus.

ABSTRACT:

Background

The clinical spectrum of Staphylococcus aureus infection ranges from asymptomatic nasal carriage to osteomyelitis, infective endocarditis (IE) and death. In this study, we evaluate potential association between the presence of specific genes in a collection of prospectively characterized S. aureus clinical isolates and clinical outcome.

Methodology/principal findings

Two hundred thirty-nine S. aureus isolates (121 methicillin-resistant S. aureus [MRSA] and 118 methicillin-susceptible S. aureus [MSSA]) were screened by array comparative genomic hybridization (aCGH) to identify genes implicated in complicated infections. After adjustment for multiple tests, 226 genes were significantly associated with severity of infection. Of these 226 genes, 185 were not in the SC

SUBMITTER: Gill SR 

PROVIDER: S-EPMC3082525 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature