ANS: aberrant neurodevelopment of the social cognition network in adolescents with autism spectrum disorders.

ABSTRACT:

Background

Autism spectrum disorders (ASD) are characterized by aberrant neurodevelopment. Although the ASD brain undergoes precocious growth followed by decelerated maturation during early postnatal period of childhood, the neuroimaging approach has not been empirically applied to investigate how the ASD brain develops during adolescence.

Methodology/principal findings

We enrolled 25 male adolescents with high functioning ASD and 25 typically developing controls for voxel-based morphometric analysis of structural magnetic resonance image. Results indicate that there is an imbalance of regional gray matter volumes and concentrations along with no global brain enlargement in adolescents with high functioning ASD relative to controls. Notably, the right inferior parietal lobul

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC3082537 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature