Hepatitis C virus receptors claudin-1 and occludin after liver transplantation and influence on early viral kinetics.

ABSTRACT:

Unlabelled

Liver transplantation (LT) is a unique model to study hepatitis C virus (HCV) entry into hepatocytes. Recent in vitro studies suggest significant changes in the expression of the HCV receptors claudin-1 and occludin after HCV infection. Our aims were: (1) to characterize claudin-1 and occludin expression in grafts from LT recipients and (2) to explore their potential influence on early HCV kinetics and their changes after HCV infection. We included 42 HCV-infected LT recipients and 19 uninfected controls. Claudin-1 and occludin were detected in paraffin-embedded liver biopsies obtained during reperfusion and 3 and 12 months after LT. HCV receptors were characterized by confocal immunofluorescence microscopy; quantification and colocalization studies were performed with d

SUBMITTER: Mensa L 

PROVIDER: S-EPMC3082584 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature