Angiotensin receptor blockers and risk of myocardial infarction: meta-analyses and trial sequential analyses of 147 020 patients from randomised trials.

ABSTRACT:

Objectives

To evaluate the cardiovascular outcomes and other outcomes associated with angiotensin receptor blockers.

Design

Systematic review of randomised controlled trials with meta-analysis and trial sequential analysis (TSA).

Data sources and study selection

Pubmed, Embase, and CENTRAL searches for randomised clinical trials, until August 2010, of angiotensin receptor blockers compared with controls (placebo/active treatment) that enrolled at least 100 participants and had a follow-up of at least one year.

Data extraction

Myocardial infarction, death, cardiovascular death, angina pectoris, stroke, heart failure, and new onset diabetes.

Results

37 randomised clinical trials included 147,020 participants and had a total follow-up of 485,166 patient yea

SUBMITTER: Bangalore S 

PROVIDER: S-EPMC3082637 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature