Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population.

ABSTRACT:

Purpose

Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL.

Methods

One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped.

Results

We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs104

SUBMITTER: Su MT 

PROVIDER: S-EPMC3082658 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature