Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome.

ABSTRACT:

Purpose

The purpose of this study was to evaluate the associations between polymorphisms in vitamin D receptor (VDR), parathyroid hormone (PTH), calcium sensing receptor (CASR), insulin receptor (INSR), and adiponectin (ADIPOQ) genes and biochemical characteristics of women with polycystic ovary syndrome (PCOS).

Methods

Serum levels of LH, FSH, estradiol, testosterone, prolactin, SHBG, glucose, IGF-1, IGFBP-1, calcium, phosphorus, PTH, 25(OH)D, and 1,25(OH)(2) D were measured in 56 women with PCOS. Furthermore, genotyping five, one, one, two, and two polymorphisms of the VDR, PTH, CASR, INSR, and ADIPOQ genes, respectively, were performed.

Results

The VDR TaqI "CC" genotype was associated with elevated serum levels of LH (p = 0.011). There were significant association

SUBMITTER: Ranjzad F 

PROVIDER: S-EPMC3082662 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature