Advances of genomic science and systems biology in renal transplantation: a review.

ABSTRACT: The diagnosis of rejection in kidney transplant patients is based on histologic classification of a graft biopsy. The current "gold standard" is the Banff 97 criteria; however, there are several limitations in classifying rejection based on biopsy samples. First, a biopsy involves an invasive procedure. Second, there is significant variance among blinded pathologists in the interpretation of a biopsy. And third, there is also variance between the histology and the molecular profiles of a biopsy. To increase the positive predictive value of classifiers of rejection, a Banff committee is developing criteria that integrate histologic and molecular data into a unified classifier that could diagnose and prognose rejection. To develop the most appropriate molecular criteria, there have been stud

SUBMITTER: Perkins D 

PROVIDER: S-EPMC3082700 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature