FLT3 inhibitors: a story of the old and the new.

ABSTRACT:

Purpose of review

Ever since the recognition that FMS-like tyrosine kinase 3 (FLT3) mutations exert a profound negative prognostic impact on the clinical outcome of patients with acute myeloid leukemia (AML), researchers have sought to find effective small-molecule inhibitors of this receptor tyrosine kinase. This review will attempt to provide a survey of the FLT3 inhibitors currently under investigation and provide a discussion on their current status in clinical trials.

Recent findings

Over the past 10 years, a number of different compounds have been studied in vitro and clinically as FLT3 inhibitors. The first inhibitors studied were hampered by cumbersome pharmacokinetics and a general lack of potency. However, some agents have shown promise in clinical trials with tran

SUBMITTER: Fathi A 

PROVIDER: S-EPMC3082742 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature