Mercury exposure and risk of cardiovascular disease in two U.S. cohorts.

ABSTRACT:

Background

Exposure to methylmercury from fish consumption has been linked to a potentially increased risk of cardiovascular disease, but evidence from prior studies is equivocal. Beneficial effects of the ingestion of fish and selenium may also modify such effects.

Methods

Among subjects from two U.S. cohorts (a total of 51,529 men and 121,700 women) whose toenail clippings had been stored, we prospectively identified incident cases of cardiovascular disease (coronary heart disease and stroke) in 3427 participants and matched them to risk-set-sampled controls according to age, sex, race, and smoking status. Toenail mercury and selenium concentrations were assessed with the use of neutron-activation analysis. Other demographic characteristics, cardiovascular risk factors, fi

SUBMITTER: Mozaffarian D 

PROVIDER: S-EPMC3082949 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature