Natural history of paclitaxel-associated acute pain syndrome: prospective cohort study NCCTG N08C1.

ABSTRACT:

Purpose

The characteristics and natural history of the paclitaxel-acute pain syndrome (P-APS) and paclitaxel's more chronic neuropathy have not been well delineated.

Methods

Patients receiving weekly paclitaxel (70 to 90 mg/m(2)) completed daily questionnaires and weekly European Organisation for Research and Treatment of Cancer (EORTC) Chemotherapy-Induced Peripheral Neuropathy (CIPN) -20 instruments during the entire course of therapy.

Results

P-APS symptoms peaked 3 days after chemotherapy. Twenty percent of patients had pain scores of 5 to 10 of 10 with the first dose of paclitaxel. Sensory neuropathy symptoms were more prominent than were motor or autonomic neuropathy symptoms. Of the sensory neuropathy symptoms, numbness and tingling were more prominent than was

SUBMITTER: Loprinzi CL 

PROVIDER: S-EPMC3082985 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature