Growth hormone plus childhood low-dose estrogen in Turner's syndrome.

ABSTRACT:

Background

Short stature and ovarian failure are characteristic features of Turner's syndrome. Although recombinant human growth hormone is commonly used to treat the short stature associated with this syndrome, a randomized, placebo-controlled trial is needed to document whether such treatment increases adult height. Furthermore, it is not known whether childhood estrogen replacement combined with growth hormone therapy provides additional benefit. We examined the independent and combined effects of growth hormone and early, ultra-low-dose estrogen on adult height in girls with Turner's syndrome.

Methods

In this double-blind, placebo-controlled trial, we randomly assigned 149 girls, 5.0 to 12.5 years of age, to four groups: double placebo (placebo injection plus childhood o

SUBMITTER: Ross JL 

PROVIDER: S-EPMC3083123 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature