Astroglial P2X7 receptor current density increased following long-term exposure to rotenone.

ABSTRACT: The role of the interaction between neurons and glial cells in the pathogenesis of neurodegenerative diseases is gaining more attention. Neuroinflammation participates in the progressive nature of diverse neurologic diseases including Parkinson's disease, Alzheimer's disease and multiple sclerosis. Activated microglia release neurotoxic molecules, which take part in the neuroinflammatory responses. Astrocytes are also key players in these responses. Reactive astrocytes secrete inflammatory factors, including tumor necrosis factor-α (TNF-α). This secretion can be regulated by extracellular ATP mediated through P2X7 receptors. However, whether the activity of astrocytic P2X7 receptors changes in Parkinson's disease and whether these changes would influence the secretion of inflammatory facto

SUBMITTER: Gao XF 

PROVIDER: S-EPMC3083135 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature