Interleukin and growth factor levels in subretinal fluid in rhegmatogenous retinal detachment: a case-control study.

ABSTRACT:

Background

Rhegmatogenous retinal detachment (RRD) is a major cause of visual loss in developed countries. Proliferative vitreoretinopathy (PVR), an eye-sight threatening complication of RRD surgery, resembles a wound-healing process with inflammation, scar tissue formation, and membrane contraction. This study was performed to determine the possible involvement of a wide range of cytokines in the future development of PVR, and to identify predictors of PVR and visual outcome.

Methodology

A multiplex immunoassay was used for the simultaneous detection of 29 different cytokines in subretinal fluid samples from patients with primary RRD. Of 306 samples that were collected and stored in our BioBank between 2001 and 2008, 21 samples from patients who developed postoperative PVR

SUBMITTER: Ricker LJ 

PROVIDER: S-EPMC3083411 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature