Dose-dependent onset of regenerative program in neutron irradiated mouse skin.

ABSTRACT:

Background

Tissue response to irradiation is not easily recapitulated by cell culture studies. The objective of this investigation was to characterize, the transcriptional response and the onset of regenerative processes in mouse skin irradiated with different doses of fast neutrons.

Methodology/principal findings

To monitor general response to irradiation and individual animal to animal variation, we performed gene and protein expression analysis with both pooled and individual mouse samples. A high-throughput gene expression analysis, by DNA oligonucleotide microarray was done with three months old C57Bl/6 mice irradiated with 0.2 and 1 Gy of mono-energetic 14 MeV neutron compared to sham irradiated controls. The results on 440 irradiation modulated genes, partially valida

SUBMITTER: Fratini E 

PROVIDER: S-EPMC3083422 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature