Evolution of the karyopherin-β family of nucleocytoplasmic transport factors; ancient origins and continued specialization.

ABSTRACT:

Background

Macromolecular transport across the nuclear envelope (NE) is achieved through nuclear pore complexes (NPCs) and requires karyopherin-βs (KAP-βs), a family of soluble receptors, for recognition of embedded transport signals within cargo. We recently demonstrated, through proteomic analysis of trypanosomes, that NPC architecture is likely highly conserved across the Eukaryota, which in turn suggests conservation of the transport mechanisms. To determine if KAP-β diversity was similarly established early in eukaryotic evolution or if it was subsequently layered onto a conserved NPC, we chose to identify KAP-β sequences in a diverse range of eukaryotes and to investigate their evolutionary history.

Results

Thirty six predicted proteomes were scanned for candidate KAP-

SUBMITTER: O'Reilly AJ 

PROVIDER: S-EPMC3083441 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature