Direction and magnitude of nicotine effects on the fMRI BOLD response are related to nicotine effects on behavioral performance.

ABSTRACT: Considerable variability across individuals has been reported in both the behavioral and fMRI blood oxygen level-dependent (BOLD) response to nicotine. We aimed to investigate (1) whether there is a heterogeneous effect of nicotine on behavioral and BOLD responses across participants and (2) if heterogeneous BOLD responses are associated with behavioral performance measures. In this double-blind, placebo-controlled, cross-over study, 41 healthy participants (19 smokers)--drawn from a larger population-based sample--performed a visual oddball task after acute challenge with 1 mg nasal nicotine. fMRI data and reaction time were recorded during performance of the task. Across the entire group of subjects, we found increased activation in the anterior cingulate cortex, middle frontal gyrus, su

SUBMITTER: Warbrick T 

PROVIDER: S-EPMC3083509 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature