Replication of association between working memory and Reelin, a potential modifier gene in schizophrenia.

ABSTRACT:

Background

The challenges in gene identification for psychiatric disorders have awakened interest toward quantitative traits and endophenotypes that are potentially more closely related to the underlying biology and provide more power in the linkage and association analyses. Previously, we successfully replicated schizophrenia linkage on chromosome 7q21-32 in Finnish families and demonstrated that an intragenic short tandem repeat (STR) allele of the regional Reelin (RELN) gene is associated with multiple cognitive traits representing central cognitive functions regarded as valid endophenotypes for schizophrenia.

Methods

Here, we used an extended sample of 290 Finnish families with schizophrenia and 375 control subjects in an association analysis between 96 SNPs and three ST

SUBMITTER: Wedenoja J 

PROVIDER: S-EPMC3083525 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature