Association of a variant in the CHRNA5-A3-B4 gene cluster region to heavy smoking in the Italian population.

ABSTRACT: Large-scale population studies have established that genetic factors contribute to individual differences in smoking behavior. Linkage and genome-wide association studies have shown many chromosomal regions and genes associated with different smoking behaviors. One study was the association of single-nucleotide polymorphisms (SNPs) in the CHRNA5-A3-B4 gene cluster to nicotine addiction. Here, we report a replication of this association in the Italian population represented by three genetically isolated populations. One, the Val Borbera, is a genetic isolate from North-Western Italy; the Cilento population, is located in South-Western Italy; and the Carlantino village is located in South-Eastern Italy. Owing to their position and their isolation, the three populations have a different envir

SUBMITTER: Sorice R 

PROVIDER: S-EPMC3083621 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature