Epistasis between neurochemical gene polymorphisms and risk for ADHD.

ABSTRACT: A number of genes with function related to synaptic neurochemistry have been genetically associated with attention deficit/hyperactivity disorder. However, susceptibility to the development of common psychiatric disorders by single variants acting alone, can so far only explain a small proportion of the heritability of the phenotype. It has been postulated that the unexplained 'dark heritability' may at least in part be due to epistatic effects, which may account for the small observed marginal associations, and the difficulties with replication of positive findings. We undertook a comprehensive exploration of pair-wise interactions between genetic variants in 24 candidate genic regions involved in monoaminergic catabolism, anabolism, release, re-uptake and signal transmission in a sample

SUBMITTER: Segurado R 

PROVIDER: S-EPMC3083627 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature