Lobophorin C and D, new kijanimicin derivatives from a marine sponge-associated actinomycetal strain AZS17.

ABSTRACT: Marine sponge Hymeniacidon sp. was collected from coastal waters of the East China Sea to isolate symbiotic microorganisms. The resulting sponge-associated actinomycete, Streptomyces carnosus strain AZS17, was cultivated in a 20 L volume of medium for production of bioactive secondary metabolites. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of kijanimicin derivatives, AS7-2 and AS9-12. Their structures were elucidated by spectroscopy and comparison with literatures. Results showed these two compounds were structurally similar to the previously reported compounds lobophorin A and B, yet differed in specific bond forms, stereochemistry and optical activities. The two novel compounds were named lobophorin C and D. In vitro cytotoxicit

SUBMITTER: Wei RB 

PROVIDER: S-EPMC3083656 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature