DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer.

ABSTRACT:

Purpose

Epigenetic alterations in tissues targeted for cancer play a causal role in carcinogenesis. Changes in DNA methylation in nontarget tissues, specifically peripheral blood, can also affect risk of malignant disease. We sought to identify specific profiles of DNA methylation in peripheral blood that are associated with bladder cancer risk and therefore serve as an epigenetic marker of disease susceptibility.

Methods

We performed genome-wide DNA methylation profiling on participants involved in a population-based incident case-control study of bladder cancer.

Results

In a training set of 112 cases and 118 controls, we identified a panel of 9 CpG loci whose profile of DNA methylation was significantly associated with bladder cancer in a masked, independent testing

SUBMITTER: Marsit CJ 

PROVIDER: S-EPMC3083868 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature