Prognostic significance and tumor biology of regional lymph node disease in patients with rhabdomyosarcoma: a report from the Children's Oncology Group.

ABSTRACT:

Purpose

Regional lymph node disease (RLND) is a component of the risk-based treatment stratification in rhabdomyosarcoma (RMS). The purpose of this study was to determine the contribution of RLND to prognosis for patients with RMS.

Patients and methods

Patient characteristics and survival outcomes for patients enrolled onto Intergroup Rhabdomyosarcoma Study IV (N = 898, 1991 to 1997) were evaluated among the following three patient groups: nonmetastatic patients with clinical or pathologic negative nodes (N0, 696 patients); patients with clinical or pathologic positive nodes (N1, 125 patients); and patients with a single site of metastatic disease (77 patients).

Results

Outcomes for patients with nonmetastatic alveolar N0 RMS were significantly better than for patient

SUBMITTER: Rodeberg DA 

PROVIDER: S-EPMC3083998 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature