Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library.

ABSTRACT: Alkaloid and terpenoid natural products display an extensive array of chemical frameworks and biological activities. However such scaffolds remain underrepresented in current screening collections and are, thus, attractive targets for the synthesis of natural product-based libraries that access underexploited regions of chemical space. Recently, we reported a systematic approach to the stereoselective synthesis of multiple alkaloid/terpenoid-like scaffolds using transition metal-mediated cycloaddition and cyclization reactions of enyne and diyne substrates assembled on a tert-butylsulfinamide lynchpin. We report herein the synthesis of a 190-membered library of alkaloid/terpenoid-like molecules using this synthetic approach. Translation to solid-phase synthesis was facilitated by the use o

SUBMITTER: Moura-Letts G 

PROVIDER: S-EPMC3084128 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature