Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival.

ABSTRACT:

Background

Constitutively active androgen receptor variants (AR-V) lacking the ligand binding domain (LBD) may promote the development of castration-resistant prostate cancer (CRPC). The expression of AR-Vs in the clinically most important metastatic site, the bone, has, however, not been well documented. Our aim was therefore to compare levels of AR-Vs in hormone-naive (HN) and CRPC bone metastases in comparison to primary PC and non-malignant prostate tissue, as well as in relation to AR protein expression, whole-genome transcription profiles and patient survival.

Methodology/principal findings

Hormone-naïve (n = 10) and CRPC bone metastases samples (n = 30) were obtained from 40 patients at metastasis surgery. Non-malignant and malignant prostate samples were acquired fro

SUBMITTER: Hornberg E 

PROVIDER: S-EPMC3084247 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature