Problem drinking and low-dose naltrexone-assisted opioid detoxification.

ABSTRACT:

Objective

The influence of alcohol use on opioid dependence is a major problem that warrants a search for more effective treatment strategies. The addition of very-low-dose naltrexone (VLNTX) to methadone taper was recently associated with reduced withdrawal intensity during detoxification. In a secondary analysis of these data, we sought to determine whether problem drinking affects detoxification outcomes and whether symptoms are influenced by VLNTX use.

Method

Opioid-dependent patients (N = 174) received naltrexone (0.125 or 0.250 mg/day) or placebo in a double-blind, randomized design during methadone-based, 6-day inpatient detoxification. Alcohol consumption was assessed at admission using the Addiction Severity Index and selfreport. Outcome measures were opioid withdra

SUBMITTER: Mannelli P 

PROVIDER: S-EPMC3084365 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature