Levothyroxine dose and risk of fractures in older adults: nested case-control study.

ABSTRACT:

Objective

To quantify the effect of levothyroxine dose on risk of fractures in older adults.

Design

Nested case-control study.

Setting

Population based health databases, Ontario, Canada.

Participants

Adults aged 70 or more prescribed levothyroxine between 1 April 2002 and 31 March 2007 and followed for fractures until 31 March 2008. Cases were cohort members admitted to hospital for any fracture, matched with up to five controls from within the cohort who had not yet had a fracture.

Main outcome measure

Primary outcome was fracture (wrist or forearm, shoulder or upper arm, thoracic spine, lumbar spine and pelvis, hip or femur, or lower leg or ankle) in relation to levothyroxine use (current, recent past, remote). Risk among current users was compared bet

SUBMITTER: Turner MR 

PROVIDER: S-EPMC3084377 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature