Computational integration of homolog and pathway gene module expression reveals general stemness signatures.

ABSTRACT: The stemness hypothesis states that all stem cells use common mechanisms to regulate self-renewal and multi-lineage potential. However, gene expression meta-analyses at the single gene level have failed to identify a significant number of genes selectively expressed by a broad range of stem cell types. We hypothesized that stemness may be regulated by modules of homologs. While the expression of any single gene within a module may vary from one stem cell type to the next, it is possible that the expression of the module as a whole is required so that the expression of different, yet functionally-synonymous, homologs is needed in different stem cells. Thus, we developed a computational method to test for stem cell-specific gene expression patterns from a comprehensive collection of 49 murin

SUBMITTER: Koeva M 

PROVIDER: S-EPMC3084730 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature