A bioinformatics classifier and database for heme-copper oxygen reductases.

ABSTRACT:

Background

Heme-copper oxygen reductases (HCOs) are the last enzymatic complexes of most aerobic respiratory chains, reducing dioxygen to water and translocating up to four protons across the inner mitochondrial membrane (eukaryotes) or cytoplasmatic membrane (prokaryotes). The number of completely sequenced genomes is expanding exponentially, and concomitantly, the number and taxonomic distribution of HCO sequences. These enzymes were initially classified into three different types being this classification recently challenged.

Methodology

We reanalyzed the classification scheme and developed a new bioinformatics classifier for the HCO and Nitric oxide reductases (NOR), which we benchmark against a manually derived gold standard sequence set. It is able to classify any give

SUBMITTER: Sousa FL 

PROVIDER: S-EPMC3084760 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature