Age- and disease-dependent HERV-W envelope allelic variation in brain: association with neuroimmune gene expression.

ABSTRACT:

Background

The glycoprotein, Syncytin-1, is encoded by a human endogenous retrovirus (HERV)-W env gene and is capable of inducing neuroinflammation. The specific allele(s) responsible for Syncytin-1 expression in the brain is uncertain. Herein, HERV-W env diversity together with Syncytin-1 abundance and host immune gene profiles were examined in the nervous system using a multiplatform approach.

Results

HERV-W env sequences were encoded by multiple chromosomal encoding loci in primary human neurons compared with less chromosomal diversity in astrocytes and microglia (p<0.05). HERV-W env RNA sequences cloned from brains of patients with systemic or neurologic diseases were principally derived from chromosomal locus 7q21.2. Within the same specimens, HERV-W env transcript leve

SUBMITTER: Bhat RK 

PROVIDER: S-EPMC3084769 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature