Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.

ABSTRACT: Nerve injury leads to sensitization mechanisms in the peripheral and central nervous system which involve transcriptional and post-transcriptional modifications in sensory nerves. To assess protein regulations in the spinal cord after injury of the sciatic nerve in the Spared Nerve Injury model (SNI) we performed a proteomic analysis using 2D-difference gel electrophoresis (DIGE) technology. Among approximately 2300 protein spots separated on each gel we detected 55 significantly regulated proteins after SNI whereof 41 were successfully identified by MALDI-TOF MS. Out of the proteins which were regulated in the DIGE analyses after SNI we focused on the carboxypeptidase A inhibitor latexin because protease dysfunctions contribute to the development of neuropathic pain. Latexin protein expre

SUBMITTER: Kuhlein HN 

PROVIDER: S-EPMC3084808 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature