L1TD1 is a marker for undifferentiated human embryonic stem cells.

ABSTRACT:

Background

Human embryonic stem cells (hESC) are stem cells capable of differentiating into cells representative of the three primary embryonic germ layers. There has been considerable interest in understanding the mechanisms regulating stem cell pluripotency, which will ultimately lead to development of more efficient methods to derive and culture hESC. In particular, Oct4, Sox2 and Nanog are transcription factors known to be important in maintenance of hESC. However, many of the downstream targets of these transcription factors are not well characterized. Furthermore, it remains unknown whether additional novel stem cell factors are involved in the establishment and maintenance of the stem cell state.

Methodology/principal findings

Here we show that a novel gene, L1TD1 (al

SUBMITTER: Wong RC 

PROVIDER: S-EPMC3084827 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature