Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species.

ABSTRACT:

Background

Systematic differentiation of amyloid (Aβ) species could be important for diagnosis of Alzheimer's disease (AD). In spite of significant progress, controversies remain regarding which species are the primary contributors to the AD pathology, and which species could be used as the best biomarkers for its diagnosis. These controversies are partially caused by the lack of reliable methods to differentiate the complicated subtypes of Aβ species. Particularly, differentiation of Aβ monomers from toxic higher molecular weight species (HrMW) would be beneficial for drug screening, diagnosis, and molecular mechanism studies. However, fast and cheap methods for these specific aims are still lacking.

Principal findings

We demonstrated the feasibility of a non-conjugated FRE

SUBMITTER: Ran C 

PROVIDER: S-EPMC3084834 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature