Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.

ABSTRACT:

Background

Urotensin II (UII) is a potent vasoconstrictor peptide, which signals through a G-protein coupled receptor (GPCR) known as GPR14 or urotensin receptor (UTR). UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, where it inhibits insulin release.

Objective

Given the reported role of UII in insulin secretion, we have performed a genetic association analysis of the UTS2 gene and flanking regions with biochemical parameters related to insulin resistance (fasting glucose, glucose 2 hours after a glucose overload, fasting insulin and insulin resistance estimated as HOMA).

Results and conclusions

We have identified several polymorphisms associated with the analysed clinical traits, not only at the UTS2 gene, bu

SUBMITTER: Saez ME 

PROVIDER: S-EPMC3084835 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature