Neurodevelopmental disruption of cortico-striatal function caused by degeneration of habenula neurons.

ABSTRACT:

Background

The habenula plays an important role on cognitive and affective functions by regulating monoamines transmission such as the dopamine and serotonin, such that its dysfunction is thought to underlie a number of psychiatric conditions. Given that the monoamine systems are highly vulnerable to neurodevelopmental insults, damages in the habenula during early neurodevelopment may cause devastating effects on the wide-spread brain areas targeted by monoamine innervations.

Methodology/principal findings

Using a battery of behavioral, anatomical, and biochemical assays, we examined the impacts of neonatal damage in the habenula on neurodevelopmental sequelae of the prefrontal cortex (PFC) and nucleus accumbens (NAcc) and associated behavioral deficits in rodents. Neonatal

SUBMITTER: Lee YA 

PROVIDER: S-EPMC3084869 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature