Unknown

Dataset Information

0

Synthesis of saturated 1,4-benzodiazepines via Pd-catalyzed carboamination reactions.

ABSTRACT: A new synthesis of 1,4-benzodiazepines and 1,4-benzodiazepin-5-ones is reported. The Pd-catalyzed coupling of N-allyl-2-aminobenzylamine derivatives with aryl bromides affords the heterocyclic products in good yield, and substrates bearing allylic methyl groups are transformed to cis-2,3-disubstituted products with >20:1 dr.

SUBMITTER: Neukom JD 

PROVIDER: S-EPMC3084890 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Synthesis of saturated 1,4-benzodiazepines via Pd-catalyzed carboamination reactions.

Neukom Joshua D JD   Aquino Alvin S AS   Wolfe John P JP  

Organic letters 20110329 9

A new synthesis of 1,4-benzodiazepines and 1,4-benzodiazepin-5-ones is reported. The Pd-catalyzed coupling of N-allyl-2-aminobenzylamine derivatives with aryl bromides affords the heterocyclic products in good yield, and substrates bearing allylic methyl groups are transformed to cis-2,3-disubstituted products with >20:1 dr. ...[more]

Similar Datasets

Unknown Synthesis of substituted tetrahydroindoloisoquinoline derivatives via intramolecular Pd-catalyzed alkene carboamination reactions.
| S-EPMC4011572 | biostudies-literature
Unknown Enantioselective Synthesis of Tetrahydroquinolines, Tetrahydroquinoxalines, and Tetrahydroisoquinolines via Pd-Catalyzed Alkene Carboamination Reactions.
| S-EPMC4242523 | biostudies-literature
Unknown Stereocontrolled synthesis of bicyclic ureas and sulfamides via Pd-catalyzed alkene carboamination reactions.
| S-EPMC6924926 | biostudies-literature
Unknown Mild conditions for the synthesis of functionalized pyrrolidines via Pd-catalyzed carboamination reactions.
| S-EPMC2758105 | biostudies-literature
Unknown Synthesis of Polycyclic Nitrogen Heterocycles via Cascade Pd-Catalyzed Alkene Carboamination/Diels-Alder Reactions.
| S-EPMC4480637 | biostudies-literature
Unknown Synthesis of cyclic guanidines via Pd-catalyzed alkene carboamination.
| S-EPMC3857308 | biostudies-literature
Unknown A concise asymmetric synthesis of cis-2,6-disubstituted N-aryl piperazines via Pd-catalyzed carboamination reactions.
| S-EPMC2730114 | biostudies-literature
Unknown Enantioconvergent synthesis of (+)-aphanorphine via asymmetric Pd-catalyzed alkene carboamination.
| S-EPMC3107030 | biostudies-literature
Unknown Stereoselective synthesis of substituted 1,3-oxazolidines via Pd-catalyzed carboamination reactions of O-vinyl-1,2-amino alcohols.
| S-EPMC3163040 | biostudies-literature
Unknown Synthesis of substituted 2-aminoimidazoles via Pd-catalyzed alkyne carboamination reactions. Application to the synthesis of preclathridine natural products.
| S-EPMC4168774 | biostudies-literature