Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome.

ABSTRACT:

Objective

In preclinical reports, restriction of dietary methionine intake was shown to enhance metabolic flexibility, improve lipid profiles, and reduce fat deposition. The present report is the outcome of a "proof of concept" study to evaluate the efficacy of dietary methionine restriction (MR) in humans with metabolic syndrome.

Methods

Twenty-six obese subjects (six male and 20 female) meeting criteria for metabolic syndrome were randomized to a diet restricted to 2 mg methionine/kg body weight per day and were provided capsules containing either placebo (n = 12) or 33 mg methionine/kg body weight per day (n = 14). Energy expenditure, body composition, insulin sensitivity, and biomarkers of metabolic syndrome were measured before and after 16 wk on the respective diets.

SUBMITTER: Plaisance EP 

PROVIDER: S-EPMC3085194 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature