Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism.

ABSTRACT:

Context

IL1b (IL1B or IL1β), a key modulator of the immune response, exerts its functions mainly via IL6 regulation. Fatty meals cause transient hypertriglyceridemia and are considered to be proinflammatory, but the extent of these responses shows high interindividual susceptibility.

Objective

We evaluated the influence of a genetic variant located in the promoter region of IL1B (-1473G/C) on fasting and postprandial lipids and IL6.

Design, setting, and participants

A total of 477 people over age 65 yr were genotyped for IL1B -1473G/C, and we evaluated fasting lipids depending on genotype. Then, 88 healthy young men were also genotyped and were fed a saturated fatty acid-rich meal. Serial blood samples were drawn for 11 h after the meal, and lipid fractions and IL6 we

SUBMITTER: Delgado-Lista J 

PROVIDER: S-EPMC3085209 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature