Genome-wide meta-analysis of joint tests for genetic and gene-environment interaction effects.

ABSTRACT:

Background

There is growing interest in the study of gene-environment interactions in the context of genome-wide association studies (GWASs). These studies will likely require meta-analytic approaches to have sufficient power.

Methods

We describe an approach for meta-analysis of a joint test for genetic main effects and gene-environment interaction effects. Using simulation studies based on a meta-analysis of five studies (total n = 10,161), we compare the power of this test to the meta-analysis of marginal test of genetic association and the meta-analysis of standard 1 d.f. interaction tests across a broad range of genetic main effects and gene-environment interaction effects.

Results

We show that the joint meta-analysis is valid and can be more powerful than classic

SUBMITTER: Aschard H 

PROVIDER: S-EPMC3085519 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature