HNF1B and JAZF1 genes, diabetes, and prostate cancer risk.

ABSTRACT:

Background

Epidemiologic studies have shown that men with type II diabetes have a lower risk of prostate cancer than non-diabetic men. Recently, common variants in two genes, HNF1B and JAZF1, were found to be associated with both of these diseases.

Methods

We examined whether the relationship between HNF1B and JAZF1 variants and decreased prostate cancer risk may potentially be mediated through diabetes in two large prospective studies, the Cancer Prevention Study II Nutrition Cohort and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Results

Three HNF1B SNPS, rs11649743, rs4430796, and rs7501939, were associated with decreased risk of prostate cancer and were also associated, with marginal statistical significance, with increased risk of diabetes.

SUBMITTER: Stevens VL 

PROVIDER: S-EPMC3086139 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature