Meta-analysis of the association between variants in SORL1 and Alzheimer disease.

ABSTRACT:

Objective

To reexamine the association between the neuronal sortilin-related receptor gene (SORL1) and Alzheimer disease (AD).

Design

Comprehensive and unbiased meta-analysis of all published and unpublished data from case-control studies for the SORL1 single-nucleotide polymorphisms (SNPs) that had been repeatedly assessed across studies.

Setting

Academic research institutions in the United States, the Netherlands, Canada, Belgium, the United Kingdom, Singapore, Japan, Sweden, Germany, France, and Italy.

Participants

All published white and Asian case-control data sets, which included a total of 12,464 cases and 17,929 controls.

Main outcome measures

Alzheimer disease according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition

SUBMITTER: Reitz C 

PROVIDER: S-EPMC3086666 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature