Identification of genes differentially expressed in benign versus malignant thyroid tumors.

ABSTRACT:

Purpose

Although fine-needle aspiration biopsy is the most useful diagnostic tool in evaluating a thyroid nodule, preoperative diagnosis of thyroid nodules is frequently imprecise, with up to 30% of fine-needle aspiration biopsy cytology samples reported as "suspicious" or "indeterminate." Therefore, other adjuncts, such as molecular-based diagnostic approaches are needed in the preoperative distinction of these lesions.

Experimental design

In an attempt to identify diagnostic markers for the preoperative distinction of these lesions, we chose to study by microarray analysis the eight different thyroid tumor subtypes that can present a diagnostic challenge to the clinician.

Results

Our microarray-based analysis of 94 thyroid tumors identified 75 genes that are differe

SUBMITTER: Prasad NB 

PROVIDER: S-EPMC3086681 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature