Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.

ABSTRACT:

Rationale

Acute lung injury and the acute respiratory distress syndrome are characterized by increased lung oxidant stress and apoptotic cell death. The contribution of epithelial cell apoptosis to the development of lung injury is unknown.

Objectives

To determine whether oxidant-mediated activation of the intrinsic or extrinsic apoptotic pathway contributes to the development of acute lung injury.

Methods

Exposure of tissue-specific or global knockout mice or cells lacking critical components of the apoptotic pathway to hyperoxia, a well-established mouse model of oxidant-induced lung injury, for measurement of cell death, lung injury, and survival.

Measurements and main results

We found that the overexpression of SOD2 prevents hyperoxia-induced BAX activation

SUBMITTER: Budinger GR 

PROVIDER: S-EPMC3086743 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature