Radiographic emphysema predicts low bone mineral density in a tobacco-exposed cohort.

ABSTRACT:

Rationale

Studies demonstrating an association between chronic obstructive pulmonary disease and low bone mineral density (BMD) implicate factors distinct from treatments and severity of lung disease in the pathogenesis of osteoporosis. Whereas emphysema has been independently associated with vascular disease and other comorbidities, its association with BMD has not been well studied.

Objectives

We explored the associations of BMD with computed tomography (CT) measures of emphysema and other risk factors in current and former smokers.

Methods

One hundred ninety subjects completed a CT scan, pulmonary function testing, questionnaires, and dual x-ray absorptiometry measurements of hip and lumbar spine BMD. Subjects were classified as having normal BMD, osteopenia, or os

SUBMITTER: Bon J 

PROVIDER: S-EPMC3086755 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature