A bioinformatics approach to the structure, function, and evolution of the nucleoprotein of the order mononegavirales.

ABSTRACT: The goal of this Bioinformatic study is to investigate sequence conservation in relation to evolutionary function/structure of the nucleoprotein of the order Mononegavirales. In the combined analysis of 63 representative nucleoprotein (N) sequences from four viral families (Bornaviridae, Filoviridae, Rhabdoviridae, and Paramyxoviridae) we predict the regions of protein disorder, intra-residue contact and co-evolving residues. Correlations between location and conservation of predicted regions illustrate a strong division between families while high- lighting conservation within individual families. These results suggest the conserved regions among the nucleoproteins, specifically within Rhabdoviridae and Paramyxoviradae, but also generally among all members of the order, reflect an evoluti

SUBMITTER: Cleveland SB 

PROVIDER: S-EPMC3086907 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature