G protein-coupled receptors: walking hand-in-hand, talking hand-in-hand?

ABSTRACT: Most cells express a panel of different G protein-coupled receptors (GPCRs) allowing them to respond to at least a corresponding variety of extracellular ligands. In order to come to an integrative well-balanced functional response these ligand-receptor pairs can often cross-regulate each other. Although most GPCRs are fully capable to induce intracellular signalling upon agonist binding on their own, many GPCRs, if not all, appear to exist and function in homomeric and/or heteromeric assemblies for at least some time. Such heteromeric organization offers unique allosteric control of receptor pharmacology and function between the protomers and might even unmask 'new' features. However, it is important to realize that some functional consequences that are proposed to originate from heterome

SUBMITTER: Vischer HF 

PROVIDER: S-EPMC3087129 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature