Effect of a direct thrombin inhibitor compared with dalteparin and unfractionated heparin on human osteoblasts.

ABSTRACT:

Purpose

Osteoporosis is a relevant problem after long term administration of unfractionated heparin (UFH) and low molecular weight heparin. Melagatran is a representative of a new group of direct thrombin inhibitors with comparable data in the prevention of thromboembolic events after orthopaedic surgery. The aim of our in vitro study was to investigate the effect of a direct thrombin inhibitor compared with dalteparin and UFH on human osteoblasts.

Materials and methods

Melagatran, dalteparin and UFH were added to primary osteoblast cultures in their therapeutic range and two decimal powers below and above. Cell number, protein synthesis, mitochondrial and alkaline phosphatase activity and collagen type I synthesis were evaluated.

Results

Melagatran showed the least i

SUBMITTER: Winkler T 

PROVIDER: S-EPMC3087215 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature